Natalizumab (Tysabri}

Natalizumab simply known as Tysabri is a disease modifying drug (DMD) for very active relapsing remitting is given to you through intravenous infusion (drip) once every four weeks. it usally takes 2-3 hours. you will have to have a blood test before you start to check for JC Virus and you will have to repeat the blood test every 6 months due to the risk of progressive multifocal leukoencephalopathy (PML), an uncommon brain infection that can lead to severe disability or even death. should you become JC positive you may have to stop Tysabri.

Side Effects

Common side effecct may include

  • urinary tract infections
  • inflammation of the nose
  • shivering
  • itchy rash (urticaria)
  • headache
  • dizziness
  • nausea, vomiting
  • joint pain
  • fever

Less common side effects may include

  • severe allergic reaction during infusion (rash, swelling of face, lips or tongue,difficulty breathing)
  • discomfort during the infusion including feeling sick, headache, dizziness
  • progressive multifocal leukoencephalopathy (PML)
  • serious infections
  • liver problems

A full list of side effects is included in the manufacturer’s Patient Information Leaflet

What Tysabri Patients Say